Summary
Go to the top of the page Help
- Official Symbol
- yy1aprovided by ZNC
- Official Full Name
- YY1 transcription factor aprovided by ZNC
- Primary source
- ZFIN:ZDB-GENE-030131-1117
- See related
- Ensembl:ENSDARG00000042796 AllianceGenome:ZFIN:ZDB-GENE-030131-1117
- Gene type
- protein coding
- RefSeq status
- VALIDATED
- Organism
- Danio rerio
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
- Also known as
- yy1; fb59g10; wu:fa16g07; wu:fb59g10
- Summary
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of gene expression. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in several structures, including eye; heart; myotome; notochord posterior region; and pronephros. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
- Orthologs
- human mouse all
- NEW
- Try the new Gene table
Try the new Transcript table
Genomic context
Go to the top of the page Help
- Location:
- chromosome: 17
- Exon count:
- 5
Annotation release | Status | Assembly | Chr | Location |
---|---|---|---|---|
106 | current | GRCz11 (GCF_000002035.6) | 17 | NC_007128.7 (30857011..30863252, complement) |
105 | previous assembly | GRCz10 (GCF_000002035.5) | 17 | NC_007128.6 (30840057..30846256, complement) |
Chromosome 17 - NC_007128.7
Genomic regions, transcripts, and products
Go to the top of the page Help
Go to reference sequence details
Go to nucleotide: Graphics FASTA GenBank
Expression
Go to the top of the page Help
See details
- Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
- Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
- BioProject: PRJEB1986
- Analysis date: Fri Dec 8 19:48:10 2017
Bibliography
Go to the top of the pageHelp
Related articles in PubMed
- A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Alves-Costa FA, et al. An Acad Bras Cienc, 2012 Jun. PMID 22584411
- Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development. Shiu WL, et al. J Biomed Sci, 2016 Feb 29. PMID 26924789, Free PMC Article
- Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis. Fu CY, et al. Nucleic Acids Res, 2017 Mar 17. PMID 27913726, Free PMC Article
- Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging. Sasik MUT, et al. Neuroscience, 2020 Jun 1. PMID 32278060
- Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Yue R, et al. Cell, 2009 Oct 30. PMID 19879840
See all (13) citations in PubMed
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
- results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development
Title: Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development.
- YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.
Title: Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.
- Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox pathway.
Title: Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.
Submit: New GeneRIF Correction
Pathways from PubChem
Go to the top of the page
Interactions
Go to the top of the page Help
Products | Interactant | Other Gene | Complex | Source | Pubs | Description |
---|
General gene information
Go to the top of the page Help
Markers
- fb59g10.x1 (e-PCR)
- UniSTS:203355
- fb5910 (e-PCR)
- UniSTS:187273
- AI522672 (e-PCR)
- UniSTS:206318
Homology
- NCBI Orthologs Orthologs from OrthoDB
Gene Ontology Provided by ZFIN
Function | Evidence Code | Pubs |
---|---|---|
enables DNA-binding transcription factor activity, RNA polymerase II-specific | IBA Inferred from Biological aspect of Ancestor | |
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA Inferred from Biological aspect of Ancestor | |
enables metal ion binding | IEA Inferred from Electronic Annotation | |
enables protein binding | IPI Inferred from Physical Interaction | PubMed |
Process | Evidence Code | Pubs |
---|---|---|
acts_upstream_of_or_within angiogenesis | IMP Inferred from Mutant Phenotype | PubMed |
acts_upstream_of_or_within brain development | IMP Inferred from Mutant Phenotype | PubMed |
acts_upstream_of_or_within heart development | IMP Inferred from Mutant Phenotype | PubMed |
acts_upstream_of_or_within positive regulation of gene expression | IMP Inferred from Mutant Phenotype | PubMed |
involved_in regulation of transcription by RNA polymerase II | IBA Inferred from Biological aspect of Ancestor |
Component | Evidence Code | Pubs |
---|---|---|
part_of PcG protein complex | IBA Inferred from Biological aspect of Ancestor | |
part_of chromatin | IBA Inferred from Biological aspect of Ancestor | |
located_in nucleus | IEA Inferred from Electronic Annotation | |
part_of transcription regulator complex | IBA Inferred from Biological aspect of Ancestor |
General protein information
Go to the top of the page Help
- Preferred Names
- transcriptional repressor protein YY1a
- Names
- transcription factor Yy1
NCBI Reference Sequences (RefSeq)
Go to the top of the page Help
NEW Try the new Transcript table
RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_212617.2 → NP_997782.1 transcriptional repressor protein YY1a
See identical proteins and their annotated locations for NP_997782.1
Status: VALIDATED
- Source sequence(s)
- BX546455
- UniProtKB/TrEMBL
- F6NKM3, Q6IQQ3, Q7T1S3
- Related
- ENSDARP00000062810.4, ENSDART00000062811.6
- Conserved Domains (4) summary
-
- COG5048
Location:211 → 350 - COG5048; FOG: Zn-finger [General function prediction only]
- sd00017
Location:270 → 290 - ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:268 → 290 - zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:283 → 308 - zf-H2C2_2; Zinc-finger double domain
- COG5048
RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...
The following sections contain reference sequences that belong to a specific genome build. Explain
Reference GRCz11 Primary Assembly
Genomic
-
NC_007128.7Reference GRCz11 Primary Assembly
- Range
- 30857011..30863252 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Go to the top of the page Help
Nucleotide | Protein | Strain | |
---|---|---|---|
Heading | Accession and Version |
Additional links
Go to the top of the pageHelp
Gene LinkOut
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
- Bgee database
- BioGPS
- CTD: Comparative Toxicogenomics Database
- Eukaryotic Promoter Database
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- PANTHER Classification System
- Addgene Non-profit plasmid repository
- Creative Biogene
- ExactAntigen/Labome
- GenScript latest version of gene cDNA ORF Clone
- OriGene