yy1a YY1 transcription factor a [Danio rerio (zebrafish)] - Gene (2024)

Summary

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Official Symbol
yy1aprovided by ZNC
Official Full Name
YY1 transcription factor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1117
See related
Ensembl:ENSDARG00000042796 AllianceGenome:ZFIN:ZDB-GENE-030131-1117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
yy1; fb59g10; wu:fa16g07; wu:fb59g10
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of gene expression. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in several structures, including eye; heart; myotome; notochord posterior region; and pronephros. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (30857011..30863252, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (30840057..30846256, complement)

Chromosome 17 - NC_007128.7yy1a YY1 transcription factor a [Danio rerio (zebrafish)] - Gene (1)Neighboring gene growth differentiation factor 7Neighboring gene tripeptidyl peptidase INeighboring gene delta(4)-desaturase, sphingolipid 2Neighboring gene Enah/Vasp-like aNeighboring gene EMAP like 1

Genomic regions, transcripts, and products

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Go to reference sequence details

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A comparative expression analysis of gene transcripts in brain tissue of non-transgenic and GH-transgenic zebrafish (Danio rerio) using a DDRT-PCR approach. Alves-Costa FA, et al. An Acad Bras Cienc, 2012 Jun. PMID 22584411
  2. Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development. Shiu WL, et al. J Biomed Sci, 2016 Feb 29. PMID 26924789, Free PMC Article
  3. Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis. Fu CY, et al. Nucleic Acids Res, 2017 Mar 17. PMID 27913726, Free PMC Article
  4. Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging. Sasik MUT, et al. Neuroscience, 2020 Jun 1. PMID 32278060
  5. Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Yue R, et al. Cell, 2009 Oct 30. PMID 19879840

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

  1. results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development

    Title: Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development.

  2. YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.

    Title: Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.

  3. Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox pathway.

    Title: Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

  • fb59g10.x1 (e-PCR)
    • UniSTS:203355
  • fb5910 (e-PCR)
    • UniSTS:187273
  • AI522672 (e-PCR)
    • UniSTS:206318

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA

Inferred from Biological aspect of Ancestor
more info

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA

Inferred from Biological aspect of Ancestor
more info

enables metal ion binding IEA

Inferred from Electronic Annotation
more info

enables protein binding IPI

Inferred from Physical Interaction
more info

PubMed
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP

Inferred from Mutant Phenotype
more info

PubMed
acts_upstream_of_or_within brain development IMP

Inferred from Mutant Phenotype
more info

PubMed
acts_upstream_of_or_within heart development IMP

Inferred from Mutant Phenotype
more info

PubMed
acts_upstream_of_or_within positive regulation of gene expression IMP

Inferred from Mutant Phenotype
more info

PubMed
involved_in regulation of transcription by RNA polymerase II IBA

Inferred from Biological aspect of Ancestor
more info

Component Evidence Code Pubs
part_of PcG protein complex IBA

Inferred from Biological aspect of Ancestor
more info

part_of chromatin IBA

Inferred from Biological aspect of Ancestor
more info

located_in nucleus IEA

Inferred from Electronic Annotation
more info

part_of transcription regulator complex IBA

Inferred from Biological aspect of Ancestor
more info

General protein information

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Preferred Names
transcriptional repressor protein YY1a
Names
transcription factor Yy1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212617.2NP_997782.1 transcriptional repressor protein YY1a

    See identical proteins and their annotated locations for NP_997782.1

    Status: VALIDATED

    Source sequence(s)
    BX546455
    UniProtKB/TrEMBL
    F6NKM3, Q6IQQ3, Q7T1S3
    Related
    ENSDARP00000062810.4, ENSDART00000062811.6
    Conserved Domains (4) summary
    COG5048
    Location:211350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:270290
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:268290
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:283308
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7Reference GRCz11 Primary Assembly

    Range
    30857011..30863252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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Nucleotide Protein Strain
Heading Accession and Version

Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases

Research Materials

yy1a YY1 transcription factor a [Danio rerio (zebrafish)] - Gene (2024)

FAQs

How many genes does Danio Rerio have? ›

p. 499 left column 3rd paragraph: "Zebrafish possess 26,206 protein-coding genes [ref 6], more than any previously sequenced vertebrate, and they have a higher number of species-specific genes in their genome than do human, mouse or chicken.

What is the transcription factor Yin Yang 1? ›

Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy. YY1 is involved in homologous recombination inhibition at guanine quadruplex sites in human cells. YY1/circCTNNB1/miR-186-5p/YY1 positive loop aggravates lung cancer progression through the Wnt pathway.

How many transcription factors are in C elegans? ›

However, the motifs for only 10% of the estimated 763 transcription factors in C. elegans have been identified so far. In this study, Narasimhan, Lambert, Yang et al. used a technique called a 'protein binding microarray' to identify the motifs for many more of the C.

How many transcription factors are in mammals? ›

Although the number of genes for the transcription factors in mammals lies around 1600, the total number of functional factors is much higher as many of those factors have multiple isoforms arising out of alternative splicing.

Why is Danio rerio important? ›

In the last 20 years, the zebrafish Danio rerio has become well-established as a model organism, particularly for the study of the genetics of early vertebrate development.

How are zebrafish related to humans? ›

And, it turns out; the fish are a lot like people. Humans and zebrafish share 70 percent of the same genes and 84 percent of human genes known to be associated with human disease have a counterpart in zebrafish.

Is Yin Yang release rare? ›

Yin Release is the manipulation of a shinobi's spiritual energy, and Yang Release is the manipulation of a shinobi's life energy. When combined together, both form Yin-Yang Release, the rarest and most powerful nature transformation in the series.

What is Yin Yang simplified? ›

Definition. The principle of Yin and Yang from Chinese philosophy is that all things exist as inseparable and contradictory opposites. Examples of Yin-Yang opposite forces are female-male, dark-light, and old-young. The pairs of equal opposites both attract and complement each other.

What is the DNA binding domain of YY1? ›

The DNA-binding domain of YY1 is composed of four C2H2 zinc fingers. Threonine 348 is located between zinc fingers 2 and 3, and threonine 378 is located between zinc fingers 3 and 4. A closer examination of these two sites revealed that they are part of a consensus linker peptide sequence.

What is unusual about the C. elegans genome? ›

elegans is one of the most intimately understood species in biology—the first animal to have its complete genome sequenced or its neural circuitry completely mapped.

How do you identify transcription factors of a gene? ›

The ChIP assay is a very powerful technique used to identify regions of a genome associated with specific proteins including but not limited to transcription factors within their native chromatin context (1). In this technique, intact cells are fixed with formaldehyde to cross-link proteins with their associated DNA.

How much DNA do we share with C. elegans? ›

On average, the amino acid similarity and identity between aligned human and C. elegans orthologous gene products are 69.3% and 49.1% respectively, and the nucleotide identity is 49.8%.

Does every gene have a transcription factor? ›

Therefore, approximately 10% of genes in the genome code for transcription factors, which makes this family the single largest family of human proteins.

Why are transcription factors important? ›

Transcription factors are vital molecules in the control of gene expression, directly controling when, where and the degree to which genes are expressed. They bind to specific sequences of DNA and control the transcription of DNA into mRNA.

What is the meaning of transcription factor? ›

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes.

Are 70 of human genes found in zebrafish? ›

Despite the apparent differences between humans and zebrafish, these freshwater fish share 70% of human genes. This similarity extends to various organs and biological processes, making zebrafish a viable model for studying diseases affecting humans. Zebrafish embryos are laid externally and can be manipulated.

How many genes do we share with zebrafish? ›

Although humans may appear to be extremely different than zebrafish, we are actually much more similar to them than you might think. In fact, 70% of human genes are found in zebrafish .

How many genes are in the lungfish genome? ›

The lungfish genome contains 17,095 ncRNA genes, including 1,042 tRNA genes, 1,771 rRNA genes, and 3,974 microRNA genes.

How many genes do fish have? ›

Genome assembly and gene annotation of major fishes in world fisheries and aquaculture.
Common nameChromosome number (2n)Number of genes
Atlantic salmon5846,598
Channel catfish5830,530
Common carp10052,610
European seabass4826,719
10 more rows

References

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